Interference between Poliomyelitis Viruses in Tissue Culture

I. TrrE ErrEc~r or ACTIVE VIRUS UPON THE MULTIPLICATION OF INFLUENZA VIRUSES IN THE CHICK EMBRYO* BY JAMES E. ZIEGLER, JR., M.D., Lieutenant, Medical Corps, United States Naval Reserve

The initial observations on the interference phenomenon were made in virus diseases of plants. In 1929, McKinney (1) observed that plants infected by tobacco mosaic virus resisted infection with a variant strain of this virus. Thung (2), in 1931, was apparently the first to study the phenomenon in detail in plants. Numerous examples of interference between plant viruses have been reported subse...

Lieutenant, Medical Corps, United States Naval Reserve

The initial observations on the interference phenomenon were made in virus diseases of plants. In 1929, McKinney (1) observed that plants infected by tobacco mosaic virus resisted infection with a variant strain of this virus. Thung (2), in 1931, was apparently the first to study the phenomenon in detail in plants. Numerous examples of interference between plant viruses have been reported subse...

Experimental study of interference between Pertussis antigens and Salk Poliomyelitis vaccine

Studies in Rodent Poliomyelitis

1. The murine virus may be grown in embryonic mouse brain-serum ultrafiltrate cultures. The virus fails to grow in embryonic chick tissue cultures or in fertilized egg preparations. 2. Some relationship can be demonstrated between the amount of nervous tissue and the infectivity of the culture. 3. Optimum titers of virus potency (10(-6)) can be obtained by adjusting the pH of the growing cultur...

STUDIES ON T H E PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSES II. A DESCRIFrlON 01~ TEE GROWTH ClmvE AND ITS RELATION TO THE CYTOPATHOGENICITY OF POLIOMYELITIS VIRUS* BY WILLIAM F. SCHERER, M.D., ArrD

The rate of change of a microbial population is commonly depicted by a growth curve. This reflection of the dynamic aspects of reproduction under relatively fixed conditions is established readily for most microbial agents by interval enumeration either of the viable forms, or of the viable and nonviable forms. Contrariwise, for viruses, an accurate temporal enumeration of the intracellular and...